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Accelerating the adoption of recombinant antibodies

The FC3R aims to replace the use of antibodies of animal origin, which present both ethical and scientific robustness problems (variability, lack of reproducibility, etc.). The antibodies most commonly used on French histology platforms have been targeted as a priority. In partnership with the Association Française d'Histotechnologie (AFH) and antibody suppliers, a pilot study was carried out to characterise the performance of alternative recombinant antibodies and share the results with the scientific community.

RESULTS BY TARGET PROTEIN

CD3 (coming soon)

CD31

CD68

CHGA

GFAP

GFP

Ki67

KRT14

Occludine

Caspase-3 (coming soon)

Dystrophin (coming soon)

Laminin (coming soon)

PROJECT DESCRIPTION

National survey (2024)

Which animal-derived antibodies are most commonly used on histology platforms in France?

Pilot study (2024-2025)

Characterisation and validation
of recombinant alternatives

  • Selection of 12 target proteins

  • 3 recombinant antibodies for each target protein sent by partner suppliers

  • Characterisation/validation by histology platforms

Sharing of results (from 2025)

Dissemination of protocols and data obtained

  • Publications on the FC3R website

  • Conference presentation (AFH)

  • Publications (Short Notes, Antibody reports), etc.

FIND OUT MORE

Links

If you're looking to replace an antibody of animal origin, contact us!

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