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Replacement : alternatives to animal models and animal products in scientific research

Call for projects of the FC3R – Results publication in March 2023

RESULTS

With this call for projects, the FC3R wished to promote innovative French research projects proposing a new strategy, method or technology favoring the Replacement - total, relative or partial - of animals and/or animal by-products used for scientific purposes: development of alternative or substitute in vitro (cell cultures, organoids, organ-on-chip), in silico (bioinformatics approaches, development of numerical models) or in chemico (biochemical toxicity studies) methods, replacement of animal by-products (fetal calf serum, extracts of basal membranes, antibodies) by synthetic and recombinant alternatives, use of cells or non-mammalian species (nematode, drosophila, zebrafish), in particular for large-scale genetic or toxicological screens, etc.

162 projects were submitted to this call. The Scientific Committee has selected 19 projects for a total funding by the FC3R of 784 467 €.

RESEARCH TOPICS FUNDED

THE LAUREATES

2COC : Development of complex human brain organoids to model glioblastoma studies

3D-renavasc : Deciphering the molecular and functional features of the renal carcinoma-specific vasculature : Relevancy of the microtumors in 3D co-culture

3DMus : 3D muscle organoids

BLOOD-CROWD : Toward an organ-on-chip to mimic blood vessels in vitro: a biomimetic model of fluid extracellular macromolecular crowding

BreasMo : Development of a 3D Bioprinting healthy model for reconstituting the breast tissue environment

CHICKTESTIS : A dynamic bird testis culture model

DTAD : Development of digital twin to estimate maternal pharmacokinetics and fetal exposure: example of the antidepressants

Endocrinodetect : A new cell line for a myriad of specific highly sensitive in-vitro hormonal bioassays to replace in vivo assays

GutScreen : Development of a screening platform for Inflammatory Bowel Disease based on an environment-controlled human colon MPS

Inv-FAE-on-chip : Development of a human intestinal follicle-associated epithelium-on-chip for identifying the physiological infection portals of Shigella and Streptococcus

IVORGA : Development of new integrated in vitro models of human organogenesis

MILISK : Microfluidic liver-skin in vitro coculture model for toxicity studies

MUTABRAIN : IPSC-derived human neurons and brain organoids development to study the pathophysiological impact of mutations identified in bipolar disorders

NOCIPLAN : Screening of Antinociceptive and Analgesic molecules using the planarian animal model

PaSpheThIm : Characterization of heterotypic spheroid models mimicking the pancreatic tumor microenvironment for the analysis of therapeutic combinations

Re-innov : Replace but innovate: a new model to understand a new side of epithelial tumorigenesis

ROSETTE : Toward a well-defined and dynamic 3D system to study the evolution of pluripotency in vitro

SAND : Rethinking and substituting animal models of pediatric cancers: contribution of the sea aenmone Nematostella vectensis

ZFishforCFCare : Restoring host innate immunity in CF

2COC : Development of complex human brain organoids to model glioblastoma studies

3D-renavasc : Deciphering the molecular and functional features of the renal carcinoma-specific vasculature : Relevancy of the microtumors in 3D co-culture

3DMus : 3D muscle organoids

BLOOD-CROWD : Toward an organ-on-chip to mimic blood vessels in vitro: a biomimetic model of fluid extracellular macromolecular crowding

BreasMo : Development of a 3D Bioprinting healthy model for reconstituting the breast tissue environment

CHICKTESTIS : A dynamic bird testis culture model

DTAD : Development of digital twin to estimate maternal pharmacokinetics and fetal exposure: example of the antidepressants

Endocrinodetect : A new cell line for a myriad of specific highly sensitive in-vitro hormonal bioassays to replace in vivo assays

GutScreen : Development of a screening platform for Inflammatory Bowel Disease based on an environment-controlled human colon MPS

Inv-FAE-on-chip : Development of a human intestinal follicle-associated epithelium-on-chip for identifying the physiological infection portals of Shigella and Streptococcus

IVORGA : Development of new integrated in vitro models of human organogenesis

MILISK : Microfluidic liver-skin in vitro coculture model for toxicity studies

MUTABRAIN : IPSC-derived human neurons and brain organoids development to study the pathophysiological impact of mutations identified in bipolar disorders

NOCIPLAN : Screening of Antinociceptive and Analgesic molecules using the planarian animal model

PaSpheThIm : Characterization of heterotypic spheroid models mimicking the pancreatic tumor microenvironment for the analysis of therapeutic combinations

Re-innov : Replace but innovate: a new model to understand a new side of epithelial tumorigenesis

ROSETTE : Toward a well-defined and dynamic 3D system to study the evolution of pluripotency in vitro

SAND : Rethinking and substituting animal models of pediatric cancers: contribution of the sea aenmone Nematostella vectensis

ZFishforCFCare : Restoring host innate immunity in CF

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