|  CONTACT  |  
FR  |  EN
CONTACT  |  
FR  |  EN

Presentation of the France 2030 Organs and Organoids on Chips Research Program (PEPR MED-OoC)

On April 29, the PEPR MED-OoC, a French research program on organs and organoids on chips, co-led by the CEA, Inserm, and CNRS, was launched. This six-year, 48-million-euro project aims to develop personalized biological models and multifunctional chips for more precise medicine with less reliance on animal testing.

24.05.24

BioValley France, France Biotech, and Netri announced on April 4, 2024, the creation of a strategic sector contract on organoids and organs on chip in France. Read the press release (in french)

Share this news

On Monday, April 29, 2024, the French scientific community reached a major milestone with the presentation of the PEPR (Priority Research and Equipment Programs, France 2030) Organs and Organoids on Chips, named MED-OoC. This consortium, co-directed by Xavier Gidrol of CEA, Jean Rosenbaum of Inserm, and Anne-Marie Gue of CNRS, aims to establish an ambitious program to develop personalized medicine through innovative and revolutionary approaches centered on organs on chip (OoC).

Highlighting the colossal challenges posed by current drug production costs and the need for sovereign production in the face of supply disruptions—such as those observed during the Covid-19 pandemic—the consortium emphasized how the emergence of new biotherapies and the growing need for personalized medicine urgently call for the development of more relevant biological models for patients (“clinical twins”). Organs on chips represent a significant advancement in this field. By creating controlled microenvironments, these devices can model physiological functions and/or biomechanical properties of organs without necessarily seeking to replicate them exactly. As an alternative to traditional animal models, these approaches also have the potential to significantly reduce the use of animal testing.

The six-year, 48-million-euro PEPR MED-OoC aims to promote the emergence of a new generation of OoC around three main challenges:

© Xavier Gidrol - Objectives and approaches of PEPR MED-OoC© Xavier Gidrol - Objectives and approaches of PEPR MED-OoC

This multidisciplinary program will mobilize all French expertise to facilitate the transfer of discoveries from the laboratory to the patient’s bedside. It will include five distinct approaches:

The presentation of the four initial targeted projects by their leaders illustrated the diversity of potential OoC applications, from tumor modeling to understanding metabolic syndrome, monitoring pancreatic islet transplants, and tissue engineering:

© Fabrice Navarro - Overview of the MAGIC project © Fabrice Navarro - Overview of the MAGIC project

The schedule anticipates the launch of the first call for projects in early 2025, marking the beginning of a new era in French medical research. The PEPR MED-OoC paves the way for more precise, effective, and patient-respectful medicine while strengthening national sovereignty and reducing animal testing.

For more information, don’t miss the PEPR MED-OoC consortium webinar organized by the FC3R on December 12, 2024!

In-depth exploration of human neural organoids

15.02.24

Discover the latest advances in modelling human nervous system development and pathologies using brain organoids.

Digital twins in life sciences

17.01.24

3 examples of innovative approaches that have the potential to reduce and replace animal models.

All 3Rs events and news
and GIS FC3R news

Find out about 3Rs events and news in France and around the world.

Submit
a training

Submit
a Short Note