Description of the training

This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.

Topics covered during the training

- Introduction to the Toxicology 21st century.
- How ToxCast and Tox21 technologies can be used in practice.
- Human Toxome Project run by Johns Hopkins University.
- Read-across.
- The role of miRNA and epigenetics in toxicology and environmental health.
- In vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling.
- Integrated testing strategies.

Species covered during the training

No particular animals or species are discussed during the training.

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